The LONG-AWAITED article describing all the work done to develop the first and only patented stem cell enhancer.

This will soon be published in a well respected peer review scientific journal. As we await the official publication, here is a summary of the scientific information validating the effects stem enhancers have on stem cells.

The first discovery was the effect of large quantities of whole Aphanizomenon- flos-aquae (AFA) on the number of circulating stem cells.

Essentially, we discovered that the comsumption of five grams and more of AFA triggered an increase of approximately 25-30 percent in the number of circulating stem cells.

This was a real breakthrough; however the consumption of such a large amount of AFA (10-20 capsules a few times a day) was impractical and too expensive for consumers. So the next step was to design a way to concentrate the molecule responsible for the effect, but first we had to identify it.

What could be present in a natural product that could support stem cell release?

In 2000, Dr. Paul Frenette's group at the Mount Sinai School of Medicine had described a class of natural compounds able to stimulate stem cell release by binding a molecule called L-selectin. The problem was that these compounds were not effective when taken orally only when injected.

Could AFA contain L-selectin lignad (binding molecule) which when taken orally, could support stem cell release?

To answer this question, an ingenious protocol was designed. We coated magnetic beads with a fusion protein in which we embedded molecules of L-selectin. These L-selectin molecules were used like fishing rods to capture a potential L-selectin ligand in AFA.

If AFA containd an L-selectin ligand, it would bind to the L-selection and we could then isolate it. Using this process, we identified the presence of a specific L-selectin ligand in AFA.

To ensure that this molecule had a biological effect of stem cells, we isolated stem cells from the blood and exposed them to the AFA L-selectin ligand. Stimulation of the L-selection leds in the body to externalization of CXCR4 on the surface membrane of stem cells.

Is it possible to quantify the density of CXCR4 at the surface of stem cells using antibodies and flow cytometry (to measure cells)?

If the ligand found in AFA was a stimulate, incubation of stem cells with the AFA L-selectin ligand would lead to externalization of CXCR4

If it was a blocker of L-selection, it would lead to a reduction in the externalization of CXCR4. In this approach we demonstrated that the molecule found in AFA is a blocker of L-selectin.

Finally, once we knew the molecule responsible for the effect on stem cell release we designed a way to concentrate it, leading to the development of..........Our stem enhancer is a 5-1 concentrate of AFA that specifically concentrates the L-selectin ligand found in AFA.

Consumption of one gram of our stemenhancer leads to a 25-30 percent increase in the number circulating stem cells in the blood.

This being said, the process was designed to concentrate not only the L-selectin ligand but also other water-soluble compounds like vitamins, minerals, phenylethylamine, phycocyanin, chlorophyll and many other compounds.

Therefore although our stemenhancer is specifically designed support stem cell release, it actually contains all the compounds present in AFA that are known to have health-promoting properties.

For More Information, please watch this informative 7 min. video.